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19-11-2011, 04:02 PM
First-Line Treatment of TB



for Drug-Sensitive TB





http://www.vb.6ocity.net/images/imgcache/2011/11/10212.jpg



Tuberculosis, which results from an infection with Mycobacterium tuberculosis, can usually be cured with a combination of first-line drugs taken for several months. Shown here are the four drugs in the standard regimen of first-line drugs. Also shown are the dates these four drugs were discovered—all more than 40 years ago.

First-Line Treatment of Tuberculosis (TB)



for Drug-Sensitive TB





http://www.vb.6ocity.net/images/imgcache/2011/11/10213.jpg


Tuberculosis, which results from an infection with Mycobacterium tuberculosis, can usually be cured with a combination of first-line drugs taken for several months. Shown here are the four drugs in the standard regimen of first-line drugs and their modes of action. Also shown are the dates these four drugs were discovered—all more than 40 years ago.

Multidrug-Resistant Tuberculosis (MDR TB)


and Possible Effective Treatments




http://www.vb.6ocity.net/images/imgcache/2011/11/10214.jpg
MDR TB occurs when a Mycobacterium tuberculosis strain is resistant to isoniazid and rifampin, two of the most powerful first-line drugs. To cure MDR TB, healthcare providers must turn to a combination of second-line drugs, several of which are shown here. . Second-line drugs may have more side effects, the treatment may last much longer, and the cost may be up to 100 times more than first-line therapy. MDR TB strains can also grow resistant to second-line drugs, further complicating treatment

Multidrug-Resistant Tuberculosis (MDR TB)



and Possible Effective Treatments

.


http://www.vb.6ocity.net/images/imgcache/2011/11/10215.jpg
MDR TB occurs when a Mycobacterium tuberculosis strain is resistant to isoniazid and rifampin, two of the most powerful first-line drugs. To cure MDR TB, healthcare providers must turn to a combination of second-line drugs, several of which are shown here. Second line drugs may have more side effects, the treatment may last much longer, and the cost may be up to 100 times more than first-line therapy. MDR TB strains can also grow resistant to second-line drugs, further complicating treatment.


Extensively Drug-Resistant Tuberculosis (XDR TB)




Diminishing Options for Treatment






http://www.vb.6ocity.net/images/imgcache/2011/11/10216.jpg
XDR TB occurs when a Mycobacterium tuberculosis strain is resistant to isoniazid and rifampin, two of the most powerful first-line drugs, as well as key drugs of the second line regimen—any fluoroquinolone and at least one of the three injectable drugs shown above. XDR TB strains may also be resistant to additional drugs, greatly complicating therapy.



Extensively Drug-Resistant Tuberculosis (XDR TB)





Diminishing Options for Treatment







http://www.vb.6ocity.net/images/imgcache/2011/11/10217.jpg
XDR TB occurs when a Mycobacterium tuberculosis strain is resistant to isoniazid and rifampin, two of the most powerful first-line drugs, as well as key drugs of the second line regimen—any fluoroquinolone and at least one of the three injectable drugs shown above. XDR TB strains may also be resistant to additional drugs, greatly complicating therapy.







New TB Drugs Under Development


http://www.vb.6ocity.net/images/imgcache/2011/11/10218.jpg
Several new types of TB drugs currently under development are shown here. NIAID has supported the development of two of these compounds, SQ-109 and PA-824, which are denoted by asterisks (*) above.





.New Tuberculosis (TB) Drugs Under Development


http://www.vb.6ocity.net/images/imgcache/2011/11/10219.jpg
Several new types of TB drugs currently under development are shown here with their mechanisms of action. NIAID has supported the development of two of these compounds, SQ-109 and PA-824, which are denoted by asterisks (*) above.










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