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18-11-2011, 09:41 PM
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Clotrimazole
Azole:
a broad spectrum antifungal developed in 1967. It was one of the first azoles to be developed. Formulations are now generic in a number of countries.
It is effective against Candida albicans and the dermatophytes. Its action is fungistatic or fungicidal, depending upon the concentration used.
This azole drug is available in a variety of dosage forms, including oral lozenges and vaginal formulations. It is also available in a variety of combinations with antibiotics and corticosteroids.
Trade Name:
Canesten* Bayer
Mycelex* Bayer
Desenex* Novartis
Oral:
Lozenges: Clotrimazole 10 mg Mycelex*
Topical: Cream: Clotrimazole 1% Desenex* Lotrimin*
- Lotion: Clotrimazole 1% Desenex* Lotrimin*
- Solution: Clotrimazole 1% Desenex*
Used for
Tinea corporis
Tinea cruris
Tinea pedis
Pityriasis versicolor
Cutaneous candidiasis
Nail and skin infections, fungal or gram positive
Safety Information
Avoid applying dressings that seal the area
Elevated liver function tests have been observed in patients using Clotrimazole lozenges.
Side Effects
Local cutaneous effects may include irritation, hypersensitivity, burning, pruritus, erythema, fissuring, or swelling.
FDA Pregnancy Category C
Oral formulation shows toxicity in animal trials. Use is not recommended during pregnancy or lactation.
Mechanism of Action / Pharmacokinetics
Clotrimazole damages the fungal cell wall and alters the permeability. It also inhibits the activity of intracellular enzymes, leading to a buildup of toxic concentrations of hydrogen peroxide within the fungal cell, causing death of the cell. Systemic absorption is minimal.
منقول
Clotrimazole
Azole:
a broad spectrum antifungal developed in 1967. It was one of the first azoles to be developed. Formulations are now generic in a number of countries.
It is effective against Candida albicans and the dermatophytes. Its action is fungistatic or fungicidal, depending upon the concentration used.
This azole drug is available in a variety of dosage forms, including oral lozenges and vaginal formulations. It is also available in a variety of combinations with antibiotics and corticosteroids.
Trade Name:
Canesten* Bayer
Mycelex* Bayer
Desenex* Novartis
Oral:
Lozenges: Clotrimazole 10 mg Mycelex*
Topical: Cream: Clotrimazole 1% Desenex* Lotrimin*
- Lotion: Clotrimazole 1% Desenex* Lotrimin*
- Solution: Clotrimazole 1% Desenex*
Used for
Tinea corporis
Tinea cruris
Tinea pedis
Pityriasis versicolor
Cutaneous candidiasis
Nail and skin infections, fungal or gram positive
Safety Information
Avoid applying dressings that seal the area
Elevated liver function tests have been observed in patients using Clotrimazole lozenges.
Side Effects
Local cutaneous effects may include irritation, hypersensitivity, burning, pruritus, erythema, fissuring, or swelling.
FDA Pregnancy Category C
Oral formulation shows toxicity in animal trials. Use is not recommended during pregnancy or lactation.
Mechanism of Action / Pharmacokinetics
Clotrimazole damages the fungal cell wall and alters the permeability. It also inhibits the activity of intracellular enzymes, leading to a buildup of toxic concentrations of hydrogen peroxide within the fungal cell, causing death of the cell. Systemic absorption is minimal.
منقول